(Pre-)Clinical Development of Novel Drugs in Kidney Medicine

We Are Sulfogenis
A New Era in Kidney Medicine

Overcoming the Growing Crisis in Kidney Medicine

Acute kidney injury is a frequent threat for hospitalized patients, feared for its substantial morbidity and mortality. Despite its huge burden and socio-economic impact, effective therapeutic approaches in the clinic, including drugs, are lacking.

Sulfogenis' Solution

Sulfur metabolism as a key mediator of kidney protection is conserved in humans. MBK2910 renders kidneys resistant against reactive oxygen species due to its unique mode of action in sulfur metabolism. Our treatment protects the kidneys from ferroptosis, the key driver of acute kidney injury.

Translational Research

Built on translational research at the Cluster of Excellence for Aging Research (CECAD), the Cologne Center for Molecular Medicine (CMMC), and the University Hospital Cologne. Access to the Center of Excellence in Nephrology — European key hub for kidney innovation at the University Hospitals Aachen, Cologne, and Düsseldorf.

Scalable Access in Kidney Medicine

MBK2910 allows a broad clinical use and equitable access due to a very favorable side-effect profile. MBK2910 will reduce mortality associated with acute kidney injury, prevent loss of kidney function, avoid dialysis, improve quality of life, and reduce total care costs. Further indications in kidney medicine are chronic kidney disease and transplantation.

For a full overview of Sulfogenis, please see our Executive Summary (PDF).

Technology

Known Mode of Action

MBK2910 increases intracellular glutathione biosynthesis and improves recovery of oxidized glutathione. MBK2910 enters tubular epithelial cells via a known transporter and limits cell death in kidneys. This unique, and broad mode of action enables MBK2910 for the treatment of a wide range of diseases.

MBK2910 Demonstrates Consistent Protective Effects

in-vitro & in-vivo

Known Pharmacokinetics

  • Biochemical modifications directly influence bioavailability and pharmacokinetics with stable pharmacodynamics.
  • Universal mode of action and modifiable pharmacokinetics enable broad usage of MBK2910 beyond kidney medicine.

mouse, in-vivo

Uninephrectomy + Renal IRI

  • Consistent and robust induction of AKI by removal of the right kidney and clamping of the left vessels for 40 minutes.
  • Improved survival and protected kidney function.
  • Prevented histopathological damage and lowered tubular injury markers.
  • Demonstrated potent anti-ferroptotic activity.

human, ex-vivo

Clinical Trial During Living Kidney Donation

  • Set-up of an accompanying clinical trial (NCT05709600) with specific, dietary interventions that mimic MBK2910's mode of action in sulfur metabolism.
  • Collection of human kidney material: conservation of MBK2910's mechanism of kidney protection in human tissue.

Expansion into Other Territories

MBK2910 protects organs from ferroptosis, a universal mode of cell death. The expansion of MBK2910 for the treatment of ferroptosis-caused diseases beyond kidney medicine includes stroke, myocardial infarction, non-alcoholic fatty liver disease, hemochromatosis, autoimmune diseases, and neurodegenerative disorders.

About Us

Meet Our Leadership Team

United by passion, vision, expertise, and shared commitment from basic, translational and clinical science — to save the lives of our patients.

Leadership team, in alphabetical order

Thomas Benzing is Professor of Medicine and Chairman of the Department II of Internal Medicine at the University of Cologne. Benzing received his MD and clinical training at the University of Freiburg, Germany. During his postdoctoral research at the Institute of Cardiovascular Physiology, University of Frankfurt and at Harvard Medical School, Boston, he focused on various aspects of signaling in kidney disease. Since 2007 Benzing is Professor and Chairman of the Department II of Internal Medicine and Director of the Kidney Research Center Cologne. Benzing is Chair of the Center for Molecular Medicine Cologne (CMMC) and also founding member of the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD). Benzing has been awarded with numerous prizes and awards including the Volhard Prize, the Ernst Jung Prize in Medicine as well as honorary fellowships by several societies including the American Society of Nephrology. He is elected member of the German National Academy of Sciences Leopoldina, Ludwig Heilmeyer Society, American Society of Clinical Investigation, American Clinical and Climatological Association, the North Rhine-Westphalian Academy of Sciences and Arts, and the Senate of the German Research Foundation.

Paolo Galfetti is a biotech executive with 30+ years of experience and track record in driving growth, innovation, and commercial success in the biotech and drug delivery industry. Galfetti is a leader with a deep understanding of scientific, regulatory, operational and business aspects, adapting at translating research breakthroughs into marketable products. He has a strong strategic and financial acumen, with proven ability to secure funding, allocate resources, and maximize shareholder value. Galfetti is committed to ethical practices, regulatory compliance, and patient-centric approaches. He is recognized for building high-performing teams and fostering a culture of collaboration and excellence. By combining leadership skills with a personal touch in rare diseases, Galfetti is able to foster a truly patient centric and companywide culture.

Dietrich Joos is a long-term Life Sciences investor with more than 30 years of experience in asset management and in the structuring and management of funds. He was Managing partner of Independent Capital Group, Senior Portfolio Manager at Roche and Pharma Analyst at UBS.
Master’s Degree in Economics and Social Sciences.

Marc Kessemeier is Managing Partner of MaKe Company GmbH and Managing Director of H&P Inkubator GmbH. Kessemeier's expertise lies in the fields of corporate finance, structuring and reorganization. He advises entrepreneurs and companies primarily in the life sciences, service, and cultural industries, on financing and the purchase or sale of companies. Kessemeier has more than 25 years of experience in building up young companies, considering the requirements for a successful exit.

Felix Köhler is a nephrologist and clinician-scientist at the Department II of Internal Medicine of the University of Cologne (led by Prof. Thomas Benzing). He received his doctorate at the Institute for Translational Research of the Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and completed his scientific training at CECAD, the Center for Molecular Medicine Cologne (CMMC), and the Department of Internal Medicine (Nephrology) & Einthoven Laboratory of Vascular and Regenerative Medicine at the Leiden University Medical Center (LUMC, the Netherlands). Köhler is elected member of the executive board of the Junior Faculty Club of the University of Cologne, of the NephroFuture Class of 2024 of the German Society of Nephrology and of the CMMC's Career Advance Program. Köhler has been awarded with numerous awards for young and upcoming clinician-scientists, including the Young Investigator Award of the German Society of Internal Medicine (DGIM) and the DZIF Doctoral Candidate Award of the German Society for Infectious Diseases (DGI).

Roman-Ulrich Müller is Professor of Nephrology and chairman of the Department of Nephrology at the Heinrich Heine University Düsseldorf. Müller began his medical career at the Universities of Freiburg and Heidelberg. After finishing medical school, he completed his scientific training at Rockefeller University (New York, USA) and Yale University (New Haven, USA). He then returned to Germany to obtain his board certification in Nephrology in the Department II of Internal Medicine at the University of Cologne, where he led the Centre for Rare and Genetic Kidney Diseases. Beside genetic kidney disease, acute kidney injury and renal organ protection are among his key interests. To move findings from the molecular biology lab to the clinic, Müller runs a translational pipeline linking basic science work to clinical trial programs.

Sylvia Ritthaler is Partner at MaKe Company GmbH and at H&P Inkubator GmbH. Ritthaler has over 15 years of experience in quality management in the life sciences industry. Her work has focused on assisting early-stage companies and laboratories in establishing and improving quality systems. She also specializes in advising companies on the development of effective project management.

Günter Schwarz is a Professor of Biochemistry and formerly dean of the Faculty of Mathematics and Natural Sciences at the University of Cologne. Schwarz received his doctorate in Biology at the Technical University Braunschweig and completed his scientific training at the Center for Molecular Medicine & Center for Structural Biology, State University of New York at Stony Brook, NY/USA. In 2008, Schwarz was appointed full Professor of Biochemistry at the University of Cologne and served as Rector's Representative for Innovation and Transfer at the University of Cologne for many years. In parallel to his scientific duties, Schwarz founded Colbourne Pharmaceuticals GmbH, and as CEO of Colbourne Pharmaceuticals GmbH has gone successfully through all aspects of implementing a scientific idea up to clinical maturity reaching the market. For his outstanding engagement between bench and bedside, Schwarz has been awarded with numerous prizes and awards including the Novartis-Preis for Therapy-related Pharmacological Research, the Horst-Bickel-Award for novel therapies in the field of inborn errors in metabolism, and the Innovation Award of the State North Rhine Westphalia.

A World Class Advisory Board

Prof. Dr. Ton Rabelink

Ton Rabelink is Professor of Internal Medicine and Nephrology, and Chairman of the Department of Internal Medicine at Leiden University Medical Center (LUMC). Rabelink is Director of the Leiden based Novo Nordisk Foundation for Stem Cell Medicine (reNEW), and CSO and co-founder of NecstGen — a non-profit, LUMC affiliated Good Manufacturing Practice (GMP) facility for cell and gene therapy. Rabelink is co-founder and was kidney-moonshot leader of the public private regenerative medicine consortium RegMedXB.

Prof. Dr. Hanns-Christian Mahler

Hanns-Christian Mahler is CEO & Board Member at ten23 health and KriyaBio. He previously led the Drug Product Services (DPS) Business Unit at Lonza AG and worked in various leadership roles such as Head Pharmaceutical Development & Supplies at Roche (2005–2015) and at Merck KGaA (2000–2005). He is adjunct faculty at the Universities of Basel, Switzerland and Frankfurt/Main, Germany and Expert at EDQM (Ph.Eur.). Mahler has extensive expertise in formulation development, process development & validation, packaging/device development and integration, sterile manufacturing, and regulatory submissions with numerous IND/IMPD and BLAs.

Prof. Marcus Conrad

Prof. Dr. Marcus Conrad is the director of the Institute of Metabolism and Cell Death at the Helmholtz Center Munich, the German Research Center for Environmental Health. Marcus Conrad is the scientist that discovered ferroptosis, a novel form of iron and reactive oxygen-dependent form of regulated cell death. He demonstrated first that the enzyme glutathione peroxidase protects from ferroptosis and today multiple pathways and underlying mechanisms have been uncovered by Marcus Conrad. He is one of the highest cited researchers world-wide and his work impacts many aspects of biology, medicine and disease.

Publications

Selected Publications

In chronological order.

  1. An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation.

    Späth MR, Arjune S, Bohl K, Rinschen MM, Falk CS, Antczak P, Grundmann F, Kubacki T, Hoyer-Allo KJR, Ignarski M, Koehler FC, Kaufmann K, Bartram MP, Wagner T, Thomas M, Lackmann JW, Wahida A, Schmaderer C, Kemmner S, Kurschat CE, Benzing T, Stippel D, Burst V, Müller RU.

    NPJ Aging · 2026 · doi.org/10.1038/s41514-026-00401-w

  2. The Interplay between Gut Microbiota and Diet-Induced Kidney Protection.

    Lopes F, Martinez-Martinez D, Späth MR, Hoyer-Allo KJR, Strubl S, Cukoski S, Knieps L, Brodesser S, Göbel H, Schwarz G, van den Berg BM, Rabelink TJ, Schermer B, Benzing T, Müller RU, Beyer A, Cabreiro F, Koehler FC.

    Kidney360 · 2026 · doi.org/10.34067/KID.0000001219

  3. Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials.

    Koehler FC, Rojas-Morales P, Müller RU.

    Experimental Physiology · 2026 · doi.org/10.1113/EP092817

  4. Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release.

    Fu CY, Kohl JB, Liebsch F, D'Andrea D, Ditrói T, Ogata S, Neuser F, Mai M, Mellis AT, Kouroussis E, Morita M, Gehling T, Santamaria-Araujo JA, Yeo SY, Endepols H, Křížková M, Kozich V, Krueger M, Hennermann JB, Barayeu U, Akaike T, Nagy P, Filipovic M, Schwarz G.

    Journal of Clinical Investigation · 2025 · doi.org/10.1172/JCI181299

  5. Developing serum proteomics based prediction models of disease progression in ADPKD.

    Aydogan Balaban HÖ, Arjune S, Grundmann F, Lackmann JW, Rauen T, Antczak P, Müller RU.

    Nature Communications · 2025 · doi.org/10.1038/s41467-025-61887-8

  6. Amino acid metabolism in kidney health and disease.

    Knol MGE, Wulfmeyer VC, Müller RU, Rinschen MM.

    Nature Reviews Nephrology · 2024 · doi.org/10.1038/s41581-024-00872-8

  7. A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism.

    Koehler FC, Fu CY, Späth MR, Hoyer-Allo KJR, Bohl K, Göbel H, Lackmann JW, Grundmann F, Osterholt T, Gloistein C, Steiner JD, Antebi A, Benzing T, Schermer B, Schwarz G, Burst V, Müller RU.

    Translational Research · 2022 · doi.org/10.1016/j.trsl.2022.02.003

  8. Insights into Glomerular Filtration and Albuminuria.

    Benzing T, Salant D.

    New England Journal of Medicine · 2021 · doi.org/10.1056/NEJMra1808786

  9. A molecular mechanism explaining albuminuria in kidney disease.

    Butt L, Unnersjö-Jess D, Höhne M, Edwards A, Binz-Lotter J, Reilly D, Hahnfeldt R, Ziegler V, Fremter K, Rinschen MM, Helmstädter M, Ebert LK, Castrop H, Hackl MJ, Walz G, Brinkkoetter PT, Liebau MC, Tory K, Hoyer PF, Beck BB, Brismar H, Blom H, Schermer B, Benzing T.

    Nature Metabolism · 2020 · doi.org/10.1038/s42255-020-0204-y

  10. Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study.

    Schwahn BC, Van Spronsen FJ, Belaidi AA, Bowhay S, Christodoulou J, Derks TG, Hennermann JB, Jameson E, König K, McGregor TL, Font-Montgomery E, Santamaria-Araujo JA, Santra S, Vaidya M, Vierzig A, Wassmer E, Weis I, Wong FY, Veldman A, Schwarz G.

    Lancet · 2015 · doi.org/10.1016/S0140-6736(15)00124-5